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Manu De Rycker

Showing results (31-40 of 49) with videos related to

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Plos Neglected Tropical Diseases|February 15, 2024
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activityMaikel Izquierdo, De Lin, Sandra O'Neill, et al.
Chemmedchem|September 19, 2015
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase LibraryAndrew Woodland, Stephen Thompson, Laura A T Cleghorn, et al.
ACS Infectious Diseases|April 11, 2020
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA SynthetaseLeah S Torrie, David A Robinson, Michael G Thomas, et al.
ACS Infectious Diseases|October 3, 2017
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovaniLeah S Torrie, Stephen Brand, David A Robinson, et al.
ACS Infectious Diseases|November 2, 2018
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovaniVictoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, et al.
ACS Infectious Diseases|January 23, 2020
The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>Richard J Wall, Sandra Carvalho, Rachel Milne, et al.
Journal of Medicinal Chemistry|July 15, 2020
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> ActivityMichael G Thomas, Manu De Rycker, Richard J Wall, et al.
Journal of Medicinal Chemistry|June 21, 2023
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of AnaloguesLaura A T Cleghorn, Richard J Wall, Sébastien Albrecht, et al.
European Journal of Medicinal Chemistry|May 20, 2022
Identification and development of a series of disubstituted piperazines for the treatment of Chagas diseaseKate McGonagle, Gary J Tarver, Juan Cantizani, et al.
Journal of Medicinal Chemistry|April 27, 2021
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral LeishmaniasisMichael Thomas, Stephen Brand, Manu De Rycker, et al.
Pageof 5

Showing results (31-40 of 49) with videos related to

Sort By:
Pageof 5
Plos Neglected Tropical Diseases|February 15, 2024
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activityMaikel Izquierdo, De Lin, Sandra O'Neill, et al.
Chemmedchem|September 19, 2015
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase LibraryAndrew Woodland, Stephen Thompson, Laura A T Cleghorn, et al.
ACS Infectious Diseases|April 11, 2020
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA SynthetaseLeah S Torrie, David A Robinson, Michael G Thomas, et al.
ACS Infectious Diseases|October 3, 2017
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovaniLeah S Torrie, Stephen Brand, David A Robinson, et al.
ACS Infectious Diseases|November 2, 2018
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovaniVictoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, et al.
ACS Infectious Diseases|January 23, 2020
The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>Richard J Wall, Sandra Carvalho, Rachel Milne, et al.
Journal of Medicinal Chemistry|July 15, 2020
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> ActivityMichael G Thomas, Manu De Rycker, Richard J Wall, et al.
Journal of Medicinal Chemistry|June 21, 2023
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of AnaloguesLaura A T Cleghorn, Richard J Wall, Sébastien Albrecht, et al.
European Journal of Medicinal Chemistry|May 20, 2022
Identification and development of a series of disubstituted piperazines for the treatment of Chagas diseaseKate McGonagle, Gary J Tarver, Juan Cantizani, et al.
Journal of Medicinal Chemistry|April 27, 2021
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral LeishmaniasisMichael Thomas, Stephen Brand, Manu De Rycker, et al.
Pageof 5