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Nature|August 13, 2013
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancersGeorgia Hatzivassiliou, Jacob R Haling, Huifen Chen, et al.Nature|February 5, 2010
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthGeorgia Hatzivassiliou, Kyung Song, Ivana Yen, et al.Plos One|October 6, 2017
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumorsMark Merchant, John Moffat, Gabriele Schaefer, et al.Molecular Cancer Therapeutics|October 15, 2011
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathwayJeffrey J Wallin, Kyle A Edgar, Jane Guan, et al.Plos One|January 26, 2018
Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumorsMark Merchant, John Moffat, Gabriele Schaefer, et al.Proceedings of the National Academy of Sciences of the United States of America|June 26, 2021
Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeuticIñaki Etxeberria, Elixabet Bolaños, Alvaro Teijeira, et al.Genetics|March 4, 2005
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase geneKyle A Edgar, Marcia Belvin, Annette L Parks, et al.Cancer Immunology Research|October 12, 2021
Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsHikmat H Assi, Chihunt Wong, Kimberly A Tipton, et al.Journal of Medicinal Chemistry|January 18, 2014
Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitorsSteven T Staben, Jianwen A Feng, Karen Lyle, et al.The Journal of Pathology|July 31, 2014
PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibitionWei Zhou, Adrian M Jubb, Karen Lyle, et al.Pageof 6