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Cell Chemical Biology|February 18, 2021
Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysisMarcus Y Chin, Jether Amos Espinosa, Grace Pohan, et al.
SLAS Discovery : Advancing Life Sciences R & D|January 8, 2025
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell modelsMarcus Y Chin, David A Joy, Madhuja Samaddar, et al.
Angewandte Chemie (International Ed. in English)|August 15, 2023
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed CellsSha Zhu, Matthew C Deen, Yanping Zhu, et al.
ACS Chemical Neuroscience|May 6, 2022
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell ModelMarcus Y Chin, Kean-Hooi Ang, Julia Davies, et al.
ACS Sensors|June 8, 2021
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pHMarcus Y Chin, Anand R Patwardhan, Kean-Hooi Ang, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 7, 2022
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter DeficiencyMegan L Koleske, Gregory McInnes, Julia E H Brown, et al.
Elife|October 24, 2023
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomesXiang Wang, Vitaliy V Bondar, Oliver B Davis, et al.
Cell Reports|August 23, 2025
Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactionsMadhuja Samaddar, Gabriel A Fitzgerald, Ann Hong Nguyen, et al.
Nature Communications|August 18, 2025
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trialBrittany N Flores, Seungyoon B Yu, Isaac V Cohen, et al.
Science Translational Medicine|December 3, 2025
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's diseaseTanya N Weerakkody, Hanna Sabelström, Shan V Andrews, et al.
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