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Journal of Medicinal Chemistry
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February 8, 2022
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, et al.
Journal of Medicinal Chemistry
|
September 12, 2018
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors
Jason G Kettle, Rana Anjum, Evan Barry, et al.
Journal of Medicinal Chemistry
|
August 12, 2024
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, et al.
Journal of Medicinal Chemistry
|
March 8, 2021
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, et al.
ACS Medicinal Chemistry Letters
|
December 20, 2023
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, et al.
Journal of Medicinal Chemistry
|
March 11, 2024
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, et al.
RSC Medicinal Chemistry
|
June 16, 2025
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors
Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, et al.
Journal of Medicinal Chemistry
|
January 16, 2024
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, et al.
Journal of Medicinal Chemistry
|
September 3, 2021
Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy
William McCoull, Scott Boyd, Martin R Brown, et al.
Journal of Medicinal Chemistry
|
September 27, 2021
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
Jeffrey W Johannes, Amber Balazs, Derek Barratt, et al.
Page
of 5
Search research articles
Search
Showing results (31-40 of 42) with videos related to
Sort By:
Page
of 5
Journal of Medicinal Chemistry
|
February 8, 2022
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, et al.
Journal of Medicinal Chemistry
|
September 12, 2018
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors
Jason G Kettle, Rana Anjum, Evan Barry, et al.
Journal of Medicinal Chemistry
|
August 12, 2024
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, et al.
Journal of Medicinal Chemistry
|
March 8, 2021
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, et al.
ACS Medicinal Chemistry Letters
|
December 20, 2023
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, et al.
Journal of Medicinal Chemistry
|
March 11, 2024
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, et al.
RSC Medicinal Chemistry
|
June 16, 2025
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors
Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, et al.
Journal of Medicinal Chemistry
|
January 16, 2024
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, et al.
Journal of Medicinal Chemistry
|
September 3, 2021
Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy
William McCoull, Scott Boyd, Martin R Brown, et al.
Journal of Medicinal Chemistry
|
September 27, 2021
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
Jeffrey W Johannes, Amber Balazs, Derek Barratt, et al.
Page
of 5