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Maricel Torrent

Showing results (21-30 of 40) with videos related to

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Bioorganic & Medicinal Chemistry Letters|February 25, 2021
Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferasesZhiqin Ji, Richard F Clark, Vikram Bhat, et al.
Journal of Medicinal Chemistry|July 14, 2018
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2008
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutationsThomas J Tucker, Sandeep Saggar, John T Sisko, et al.
Journal of Medicinal Chemistry|October 2, 2008
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant virusesThomas J Tucker, John T Sisko, Robert M Tynebor, et al.
Bioorganic & Medicinal Chemistry Letters|March 4, 2017
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED bindingMichael L Curtin, Marina A Pliushchev, Huan-Qiu Li, et al.
Nature|February 5, 2025
Synthetic lethality of mRNA quality control complexes in cancerVivian Prindle, Adam E Richardson, Kimberly R Sher, et al.
Journal of Medicinal Chemistry|April 24, 2020
Discovery of <i>N</i>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second BromodomainGeorge S Sheppard, Le Wang, Steven D Fidanze, et al.
Bioorganic & Medicinal Chemistry Letters|April 11, 2006
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSPChristopher D Cox, Maricel Torrent, Michael J Breslin, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSPMark E Fraley, Robert M Garbaccio, Kenneth L Arrington, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubilityRobert M Garbaccio, Mark E Fraley, Edward S Tasber, et al.
Pageof 4

Showing results (21-30 of 40) with videos related to

Sort By:
Pageof 4
Bioorganic & Medicinal Chemistry Letters|February 25, 2021
Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferasesZhiqin Ji, Richard F Clark, Vikram Bhat, et al.
Journal of Medicinal Chemistry|July 14, 2018
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2008
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutationsThomas J Tucker, Sandeep Saggar, John T Sisko, et al.
Journal of Medicinal Chemistry|October 2, 2008
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant virusesThomas J Tucker, John T Sisko, Robert M Tynebor, et al.
Bioorganic & Medicinal Chemistry Letters|March 4, 2017
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED bindingMichael L Curtin, Marina A Pliushchev, Huan-Qiu Li, et al.
Nature|February 5, 2025
Synthetic lethality of mRNA quality control complexes in cancerVivian Prindle, Adam E Richardson, Kimberly R Sher, et al.
Journal of Medicinal Chemistry|April 24, 2020
Discovery of <i>N</i>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second BromodomainGeorge S Sheppard, Le Wang, Steven D Fidanze, et al.
Bioorganic & Medicinal Chemistry Letters|April 11, 2006
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSPChristopher D Cox, Maricel Torrent, Michael J Breslin, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSPMark E Fraley, Robert M Garbaccio, Kenneth L Arrington, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubilityRobert M Garbaccio, Mark E Fraley, Edward S Tasber, et al.
Pageof 4