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Analytical Biochemistry|January 13, 2004
A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinaseDavid Casper, Marina Bukhtiyarova, Eric B Springman
Protein Expression and Purification|August 6, 2004
Improved expression, purification, and crystallization of p38alpha MAP kinaseMarina Bukhtiyarova, Katrina Northrop, Xiaomei Chai, et al.
Biochemistry|April 20, 2007
Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT stateMarina Bukhtiyarova, Michael Karpusas, Katrina Northrop, et al.
Biochemistry|March 27, 2010
Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinasesHaridasan V Namboodiri, Marina Bukhtiyarova, Joseph Ramcharan, et al.
Bioorganic & Medicinal Chemistry Letters|October 12, 2010
The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activityFouzia Machrouhi, Nouara Ouhamou, Keith Laderoute, et al.
Bioorganic & Medicinal Chemistry Letters|August 25, 2009
Structure-based design of substituted biphenyl ethylene ethers as ligands binding in the hydrophobic pocket of gp41 and blocking the helical bundle formationBin Liu, Rhoda W Joseph, Bruce D Dorsey, et al.
Bioorganic & Medicinal Chemistry Letters|October 5, 2010
Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1Bin Liu, Younghee Lee, Jinming Zou, et al.
Chemistry & Biology|February 14, 2002
Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMRSharon J Archer, Daniel M Camac, Zhongren J Wu, et al.
Bioorganic & Medicinal Chemistry Letters|October 22, 2011
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD)Kristofer Moffett, Zenon Konteatis, Duyan Nguyen, et al.
Bioorganic & Medicinal Chemistry Letters|September 20, 2005
Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modesEnrique L Michelotti, Kristofer K Moffett, Duyan Nguyen, et al.
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