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Disease Models & Mechanisms|May 26, 2026
Molecular features of a Huntington's disease knock-in minipigAnastasiia Kolesnikova, Kirupa Sathasivam, Solaleh Khoramian Tusi, et al.Molecular Therapy. Nucleic Acids|July 8, 2024
CircHTT(2,3,4,5,6) - co-evolving with the HTT CAG-repeat tract - modulates Huntington's disease phenotypesJasmin Morandell, Alan Monziani, Martina Lazioli, et al.Nature Communications|April 12, 2024
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeatZachariah L McLean, Dadi Gao, Kevin Correia, et al.Nature Genetics|January 22, 2025
In vivo CRISPR-Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington's diseaseRicardo Mouro Pinto, Ryan Murtha, António Azevedo, et al.Biorxiv : the Preprint Server for Biology|August 12, 2025
Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansionEunhye Lee, Wonju Kim, David H Beier, et al.Proceedings of the National Academy of Sciences of the United States of America|March 2, 2026
Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansionEunhye Lee, Wonju Kim, David H Beier, et al.Human Molecular Genetics|March 24, 2017
High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgroundsSeth A Ament, Jocelynn R Pearl, Andrea Grindeland, et al.Plos One|November 27, 2013
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in miceSabine M Hölter, Mary Stromberg, Marina Kovalenko, et al.Biorxiv : the Preprint Server for Biology|November 22, 2024
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat BindingElla W Mathews, Sydney R Coffey, Annette Gärtner, et al.Nature Communications|November 14, 2025
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat BindingElla W Mathews, Sydney R Coffey, Annette Gärtner, et al.Pageof 2