Showing results (41-50 of 50) with videos related to
Sort By:
Pageof 5
You have reached the last page of results.This site can display upto 50 results.
Journal of Medicinal Chemistry|August 24, 2011
2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activityGregory R Ott, Gregory J Wells, Tho V Thieu, et al.Bioorganic & Medicinal Chemistry Letters|August 3, 2011
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitorsMark W Holladay, Brian T Campbell, Martin W Rowbottom, et al.Journal of Medicinal Chemistry|May 19, 2012
A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779Benjamin J Dugan, Diane E Gingrich, Eugen F Mesaros, et al.Journal of Medicinal Chemistry|August 22, 2008
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine modelsRobert L Hudkins, James L Diebold, Ming Tao, et al.JCI Insight|November 3, 2017
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatmentAmar N Mirza, Micah A Fry, Nicole M Urman, et al.Molecular Cancer Therapeutics|February 10, 2012
CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activityJoyce James, Bruce Ruggeri, Robert C Armstrong, et al.Journal of Medicinal Chemistry|December 7, 2011
Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitorsEugen F Mesaros, Tho V Thieu, Gregory J Wells, et al.ACS Chemical Neuroscience|March 4, 2022
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand ComplexesAndrew D Cansfield, Mark A Ator, Joydeep Banerjee, et al.Journal of Medicinal Chemistry|August 17, 2016
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)Gregory R Ott, Mangeng Cheng, Keith S Learn, et al.Journal of Medicinal Chemistry|December 16, 2011
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600EMartin W Rowbottom, Raffaella Faraoni, Qi Chao, et al.Pageof 5