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ACS Chemical Neuroscience
|
August 22, 2020
Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice
Danielle N Adank, Mary M Lunzer, Mark D Ericson, et al.
ACS Pharmacology & Translational Science
|
April 18, 2024
Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]
Mark D Ericson, Katie T Freeman, Courtney M Larson, et al.
Journal of Medicinal Chemistry
|
June 12, 2023
Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH<sub>2</sub>] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH<sub>2</sub>]
Mark D Ericson, Linh T Tran, Sarah S Mathre, et al.
ACS Chemical Neuroscience
|
January 20, 2021
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R
Mark D Ericson, Erica M Haslach, Sathya M Schnell, et al.
International Journal of Molecular Sciences
|
June 28, 2023
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands
Mark D Ericson, Katie T Freeman, Travis M LaVoi, et al.
International Journal of Obesity (2005)
|
December 31, 2024
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Brittany Galuppo, Prabhath Mannam, Jacopo Bonet, et al.
Journal of Medicinal Chemistry
|
May 8, 2023
Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign"
Skye R Doering, Katie Freeman, Ginamarie Debevec, et al.
Journal of Medicinal Chemistry
|
April 22, 2021
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign
Skye R Doering, Katie Freeman, Ginamarie Debevec, et al.
Journal of Medicinal Chemistry
|
January 20, 2025
N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists
Nicholas A Weirath, Jonathan W P Zajac, Haley M Donow, et al.
Journal of Medicinal Chemistry
|
October 1, 2021
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist
Mark D Ericson, Skye R Doering, Courtney M Larson, et al.
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Search research articles
Search
Showing results (21-30 of 32) with videos related to
Sort By:
Page
of 4
ACS Chemical Neuroscience
|
August 22, 2020
Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice
Danielle N Adank, Mary M Lunzer, Mark D Ericson, et al.
ACS Pharmacology & Translational Science
|
April 18, 2024
Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]
Mark D Ericson, Katie T Freeman, Courtney M Larson, et al.
Journal of Medicinal Chemistry
|
June 12, 2023
Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH<sub>2</sub>] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH<sub>2</sub>]
Mark D Ericson, Linh T Tran, Sarah S Mathre, et al.
ACS Chemical Neuroscience
|
January 20, 2021
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R
Mark D Ericson, Erica M Haslach, Sathya M Schnell, et al.
International Journal of Molecular Sciences
|
June 28, 2023
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands
Mark D Ericson, Katie T Freeman, Travis M LaVoi, et al.
International Journal of Obesity (2005)
|
December 31, 2024
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Brittany Galuppo, Prabhath Mannam, Jacopo Bonet, et al.
Journal of Medicinal Chemistry
|
May 8, 2023
Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign"
Skye R Doering, Katie Freeman, Ginamarie Debevec, et al.
Journal of Medicinal Chemistry
|
April 22, 2021
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign
Skye R Doering, Katie Freeman, Ginamarie Debevec, et al.
Journal of Medicinal Chemistry
|
January 20, 2025
N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists
Nicholas A Weirath, Jonathan W P Zajac, Haley M Donow, et al.
Journal of Medicinal Chemistry
|
October 1, 2021
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist
Mark D Ericson, Skye R Doering, Courtney M Larson, et al.
Page
of 4