Showing results (21-30 of 38) with videos related to
Sort By:
Pageof 4
Journal of Medicinal Chemistry|November 13, 2004
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivoCraig W Lindsley, David D Wisnoski, William H Leister, et al.The Journal of Pharmacology and Experimental Therapeutics|December 21, 2004
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral modelsGene G Kinney, Julie A O'Brien, Wei Lemaire, et al.Journal of Medicinal Chemistry|July 18, 2009
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs)Helen J Mitchell, William P Dankulich, George D Hartman, et al.Neuropharmacology|December 1, 2015
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effectsRobert W Gould, Michael T Nedelcovych, Xuewen Gong, et al.Bioorganic & Medicinal Chemistry Letters|August 1, 2016
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in dispositionMichael R Wood, Meredith J Noetzel, James C Tarr, et al.Bioorganic & Medicinal Chemistry Letters|May 20, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.Bioorganic & Medicinal Chemistry Letters|November 2, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.The Journal of Biological Chemistry|October 23, 2009
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glandsAzriel Schmidt, Shun-Ichi Harada, Donald B Kimmel, et al.Journal of Medicinal Chemistry|September 17, 2004
Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosisPaul J Coleman, Karen M Brashear, Ben C Askew, et al.Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.Pageof 4