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Mark L Chapman

Showing results (11-20 of 18) with videos related to

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Proceedings of the National Academy of Sciences of the United States of America|July 3, 2013
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channelsKen McCormack, Sonia Santos, Mark L Chapman, et al.
British Journal of Pharmacology|January 28, 2015
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitabilityClaire Elizabeth Payne, Adam R Brown, Jonathon W Theile, et al.
Bioorganic & Medicinal Chemistry|October 23, 2010
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic painMarc J C Scanio, Lei Shi, Irene Drizin, et al.
Plos One|April 7, 2016
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic ReleaseAristos J Alexandrou, Adam R Brown, Mark L Chapman, et al.
Bioorganic & Medicinal Chemistry Letters|September 22, 2010
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivativesMichael E Kort, Robert N Atkinson, James B Thomas, et al.
Bioorganic & Medicinal Chemistry|May 27, 2008
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic painIrene Drizin, Robert J Gregg, Marc J C Scanio, et al.
Journal of Medicinal Chemistry|January 8, 2008
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory painMichael E Kort, Irene Drizin, Robert J Gregg, et al.
Journal of Medicinal Chemistry|July 7, 2017
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na<sub>V</sub>1.7Nigel A Swain, Dave Batchelor, Serge Beaudoin, et al.
Pageof 2

Showing results (11-20 of 18) with videos related to

Sort By:
Pageof 2
You have reached the last page of results.This site can display upto 18 results.
Proceedings of the National Academy of Sciences of the United States of America|July 3, 2013
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channelsKen McCormack, Sonia Santos, Mark L Chapman, et al.
British Journal of Pharmacology|January 28, 2015
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitabilityClaire Elizabeth Payne, Adam R Brown, Jonathon W Theile, et al.
Bioorganic & Medicinal Chemistry|October 23, 2010
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic painMarc J C Scanio, Lei Shi, Irene Drizin, et al.
Plos One|April 7, 2016
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic ReleaseAristos J Alexandrou, Adam R Brown, Mark L Chapman, et al.
Bioorganic & Medicinal Chemistry Letters|September 22, 2010
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivativesMichael E Kort, Robert N Atkinson, James B Thomas, et al.
Bioorganic & Medicinal Chemistry|May 27, 2008
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic painIrene Drizin, Robert J Gregg, Marc J C Scanio, et al.
Journal of Medicinal Chemistry|January 8, 2008
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory painMichael E Kort, Irene Drizin, Robert J Gregg, et al.
Journal of Medicinal Chemistry|July 7, 2017
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na<sub>V</sub>1.7Nigel A Swain, Dave Batchelor, Serge Beaudoin, et al.
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