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Cell Reports|December 20, 2024
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4AJuan Kochen Rossi, Cristina Nuevo-Tapioles, Rachel A O'Keefe, et al.Science Signaling|July 18, 2019
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancerDevon R Blake, Angelina V Vaseva, Richard G Hodge, et al.Pharmacology Research & Perspectives|August 5, 2022
Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpPEmily M J Fennell, Lucas J Aponte-Collazo, Joshua D Wynn, et al.The Journal of Biological Chemistry|October 24, 2021
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancerJ Nathaniel Diehl, Jennifer E Klomp, Kayla R Snare, et al.Biorxiv : the Preprint Server for Biology|January 23, 2026
Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor ResistanceKristina Drizyte-Miller, Seamus E Degan, Ryan D Mouery, et al.Biorxiv : the Preprint Server for Biology|May 4, 2026
Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancerWen-Hsuan Chang, Alec J Vaughan, Addison G Stamey, et al.Science Signaling|December 19, 2023
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signalingAntje Schaefer, Richard G Hodge, Haisheng Zhang, et al.Molecular Cell|February 18, 2006
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosisTrever G Bivona, Steven E Quatela, Brian O Bodemann, et al.Nature|December 13, 2019
KRAS4A directly regulates hexokinase 1Caroline R Amendola, James P Mahaffey, Seth J Parker, et al.Plos Medicine|July 21, 2010
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinomaJeran K Stratford, David J Bentrem, Judy M Anderson, et al.Pageof 31