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Blood|November 16, 2020
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cellsChristine Surka, Liqing Jin, Nathan Mbong, et al.
Blood|June 29, 2026
NSD2 Degradation Remediates the Oncogenic Cistrome in t(4;14) Multiple MyelomaBo Hu, Jacob Edwards, Hardik Modi, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|August 11, 2025
Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancerSurendra Nayak, John D Norris, Massimo Ammirante, et al.
Blood Cancer Discovery|November 3, 2025
Golcadomide: An Oral CELMoD Agent Targeting IKZF1/3 for Diffuse Large B-cell LymphomaZhongying Mo, Lynda Groocock, Scott Wood, et al.
Journal of Medicinal Chemistry|February 11, 2026
Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin LymphomaDeborah S Mortensen, Hunter P Shunatona, Natalie Holmberg-Douglas, et al.
Molecular Cell|February 5, 2010
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situJames E Brownell, Michael D Sintchak, James M Gavin, et al.
Molecular Cancer Therapeutics|September 8, 2017
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple MyelomaRonan Le Moigne, Blake T Aftab, Stevan Djakovic, et al.
Nature|April 11, 2009
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerTeresa A Soucy, Peter G Smith, Michael A Milhollen, et al.
Journal of Medicinal Chemistry|July 10, 2026
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365Deborah S Mortensen, Surendra Nayak, Veronique Plantevin-Krenitsky, et al.
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