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Journal of Medicinal Chemistry|August 11, 2015
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3Kim Huard, Allyn T Londregan, Gregory Tesz, et al.
Journal of Medicinal Chemistry|April 10, 2018
Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac FibrosisElnaz Menhaji-Klotz, Kevin D Hesp, Allyn T Londregan, et al.
Molecular Cancer Therapeutics|March 11, 2014
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trialsChristine Fritsch, Alan Huang, Christian Chatenay-Rivauday, et al.
Journal of Medicinal Chemistry|October 19, 2017
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 ModulatorsMarkus Boehm, Kevin Beaumont, Rhys Jones, et al.
ACS Chemical Biology|July 9, 2016
Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in MetabolismKay Ahn, Markus Boehm, Matthew F Brown, et al.
Bioorganic & Medicinal Chemistry Letters|November 17, 2012
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitorsSamit K Bhattacharya, Gary E Aspnes, Scott W Bagley, et al.
Journal of Medicinal Chemistry|September 9, 2015
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)Kentaro Futatsugi, Daniel W Kung, Suvi T M Orr, et al.
Journal of Medicinal Chemistry|November 2, 2022
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic SteatohepatitisKentaro Futatsugi, Shawn Cabral, Daniel W Kung, et al.
Journal of Medicinal Chemistry|August 5, 2016
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic NephropathyKimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, et al.
Journal of Medicinal Chemistry|February 21, 2023
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite LossMichelle R Garnsey, Aaron C Smith, Jana Polivkova, et al.
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