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European Journal of Medicinal Chemistry|December 12, 2018
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studiesAgnese C Pippione, Stefano Sainas, Parveen Goyal, et al.Journal of Medicinal Chemistry|June 26, 2018
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase InhibitorsStefano Sainas, Agnese C Pippione, Elisa Lupino, et al.ACS Pharmacology & Translational Science|December 19, 2024
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) InhibitorsMarco Tarullo, Guillermo Fernandez Rodriguez, Alessia Iaiza, et al.European Journal of Medicinal Chemistry|May 12, 2026
Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitorStefano Sainas, Chiara Vigato, Paola Circosta, et al.Journal of Medicinal Chemistry|October 22, 2025
Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor AntagonistsFederica Blua, Francesca Boccato, Carola Buccellati, et al.Journal of Medicinal Chemistry|April 12, 2021
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl MoietyStefano Sainas, Marta Giorgis, Paola Circosta, et al.Cell Death & Disease|June 30, 2022
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemiaMohammad Houshmand, Nicoletta Vitale, Francesca Orso, et al.Journal of Medicinal Chemistry|September 26, 2022
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl MoietyStefano Sainas, Marta Giorgis, Paola Circosta, et al.Pageof 4