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Proceedings of the National Academy of Sciences of the United States of America|November 6, 2020
Evolution of insulin at the edge of foldability and its medical implicationsNischay K Rege, Ming Liu, Yanwu Yang, et al.Proceedings of the National Academy of Sciences of the United States of America|March 30, 2010
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsBrian J Smith, Kun Huang, Geoffrey Kong, et al.The Journal of Biological Chemistry|September 22, 2007
The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceKun Huang, Shu Jin Chan, Qing-xin Hua, et al.The Journal of Biological Chemistry|January 29, 2010
An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic designYanwu Yang, Aneta Petkova, Kun Huang, et al.Journal of Molecular Biology|July 28, 2004
How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptorKun Huang, Bin Xu, Shi-Quan Hu, et al.The Journal of Biological Chemistry|February 2, 2020
"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolutionNischay K Rege, Ming Liu, Balamurugan Dhayalan, et al.The Journal of Biological Chemistry|November 9, 2017
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native proteinMichael D Glidden, Khadijah Aldabbagh, Nelson B Phillips, et al.Diabetes|March 7, 2020
Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of YouthJinhong Sun, Yi Xiong, Xin Li, et al.Nature|January 11, 2013
How insulin engages its primary binding site on the insulin receptorJohn G Menting, Jonathan Whittaker, Mai B Margetts, et al.Journal of Diabetes Science and Technology|July 1, 2025
Evolution of the Artificial Pancreas: Components and Integration-CGMs, Insulin, and AP SystemsRichard M Bergenstal, Adam Heller, Marc D Breton, et al.Pageof 13