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Antimicrobial Agents and Chemotherapy|May 28, 2015
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo ImagingAmanda Fortes Francisco, Michael D Lewis, Shiromani Jayawardhana, et al.
The Biochemical Journal|June 7, 2002
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulumShane R Wilkinson, Martin C Taylor, Said Touitha, et al.
The Journal of Biological Chemistry|February 14, 2002
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxinShane R Wilkinson, David J Meyer, Martin C Taylor, et al.
Chemical Biology & Drug Design|August 24, 2017
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR studyGrigoris Zoidis, Andrew Tsotinis, Alexandra Tsatsaroni, et al.
Plos Neglected Tropical Diseases|March 21, 2020
Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infectionMartin C Taylor, Alexander Ward, Francisco Olmo, et al.
Molecules (Basel, Switzerland)|June 21, 2020
Challenges in Chagas Disease Drug DevelopmentAmanda F Francisco, Shiromani Jayawardhana, Francisco Olmo, et al.
Antimicrobial Agents and Chemotherapy|May 5, 2025
Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas diseaseShiromani Jayawardhana, Francisco Olmo, Amanda Fortes Francisco, et al.
Plos Pathogens|November 13, 2023
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in miceShiromani Jayawardhana, Alexander I Ward, Amanda F Francisco, et al.
The Biochemical Journal|December 16, 2006
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpressionLucía Piacenza, Florencia Irigoín, María Noel Alvarez, et al.
Nucleic Acids Research|September 25, 2010
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma bruceiSamson O Obado, Christopher Bot, Maria C Echeverry, et al.
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