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Journal of Medicinal Chemistry|August 22, 2022
Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of EndometriosisAbdelrahman Mohamed, Mohamed Salah, Mariam Tahoun, et al.European Journal of Medicinal Chemistry|June 16, 2014
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linkerAhmed S Abdelsamie, Emmanuel Bey, Nina Hanke, et al.Journal of Medicinal Chemistry|October 28, 2010
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseasesAlexander Oster, Stefan Hinsberger, Ruth Werth, et al.European Journal of Medicinal Chemistry|September 1, 2015
Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzymeAhmed S Abdelsamie, Emmanuel Bey, Emanuele M Gargano, et al.The Journal of Steroid Biochemistry and Molecular Biology|May 12, 2009
Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cellsPatricia Kruchten, Ruth Werth, Emmanuel Bey, et al.Chemmedchem|February 22, 2011
Bicyclic substituted hydroxyphenylmethanone type inhibitors of 17 β-hydroxysteroid dehydrogenase Type 1 (17 β-HSD1): the role of the bicyclic moietyAlexander Oster, Tobias Klein, Claudia Henn, et al.Molecular and Cellular Endocrinology|October 28, 2008
Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitorsSandrine Marchais-Oberwinkler, Martin Frotscher, Erika Ziegler, et al.Journal of Medicinal Chemistry|December 30, 2010
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseasesSandrine Marchais-Oberwinkler, Marie Wetzel, Erika Ziegler, et al.Journal of Enzyme Inhibition and Medicinal Chemistry|April 5, 2012
Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitroÁgnes Berényi, Martin Frotscher, Sandrine Marchais-Oberwinkler, et al.Journal of Medicinal Chemistry|January 20, 2006
Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acidsOla I A Salem, Martin Frotscher, Christiane Scherer, et al.Pageof 4