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Molecular and Cellular Endocrinology|October 14, 2008
The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2Yaseen A Al-Soud, Emmanuel Bey, Alexander Oster, et al.Bioorganic & Medicinal Chemistry|April 24, 2010
Novel estrone mimetics with high 17beta-HSD1 inhibitory activityAlexander Oster, Tobias Klein, Ruth Werth, et al.Plos One|August 1, 2015
17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine OrthologEmanuele M Gargano, Giuseppe Allegretta, Enrico Perspicace, et al.Bioorganic & Medicinal Chemistry|June 3, 2008
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseasesEmmanuel Bey, Sandrine Marchais-Oberwinkler, Patricia Kruchten, et al.European Journal of Medicinal Chemistry|June 9, 2019
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluationAhmed S Abdelsamie, Mohamed Salah, Lorenz Siebenbürger, et al.Journal of Medicinal Chemistry|June 27, 2023
Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse ModelMohamed Salah, Mariam Tahoun, Jeannette Rudzitis-Auth, et al.European Journal of Medicinal Chemistry|November 18, 2016
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle studyAhmed S Abdelsamie, Chris J van Koppen, Emmanuel Bey, et al.Molecular Nutrition & Food Research|July 9, 2020
A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of Their EstrogenicityLuca Dellafiora, Marco Milioli, Angela Falco, et al.Journal of Medicinal Chemistry|October 17, 2009
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivityEmmanuel Bey, Sandrine Marchais-Oberwinkler, Matthias Negri, et al.Journal of Medicinal Chemistry|October 16, 2008
Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)Emmanuel Bey, Sandrine Marchais-Oberwinkler, Ruth Werth, et al.Pageof 4