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Biochemical and Biophysical Research Communications|October 23, 2019
Ensemble structural analyses depict the regulatory mechanism of non-phosphorylated human MAP2K4Takashi Matsumoto, Akihito Yamano, Yuka Murakawa, et al.Biochemical and Biophysical Research Communications|September 12, 2017
High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7Takayoshi Kinoshita, Takuma Hashimoto, Yuri Sogabe, et al.Bioorganic & Medicinal Chemistry Letters|December 23, 2014
5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented mannerYuri Sogabe, Takashi Matsumoto, Takuma Hashimoto, et al.Biochemical and Biophysical Research Communications|March 1, 2024
Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivitySeisuke Hasegawa, Mayu Yoshida, Haruna Nagao, et al.Biochemical and Biophysical Research Communications|March 19, 2016
A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7Yuri Sogabe, Takuma Hashimoto, Takashi Matsumoto, et al.Bioorganic & Medicinal Chemistry Letters|July 7, 2026
Identification of TYK2 activators. Part 2: Optimization of terminal alkyne substituents to enhance activation potencyHirokazu Matsumoto, Tien-Cheng Wang, Fumio Nakajima, et al.Biochemical and Biophysical Research Communications|September 21, 2022
Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2α1-selective inhibitorsAsaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, et al.Journal of Medicinal Chemistry|September 16, 2021
Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine KinaseWataru Kawahata, Tokiko Asami, Takao Kiyoi, et al.Acta Crystallographica. Section F, Structural Biology Communications|December 6, 2021
Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformationSetsu Nakae, Maho Kitamura, Daisuke Fujiwara, et al.Bioorganic & Medicinal Chemistry Letters|August 7, 2024
Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitorsSeigo Yumura, Daisuke Kitagawa, Kei Moritsugu, et al.Pageof 7