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Journal of Medicinal Chemistry|December 15, 2017
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)Nicola E A Chessum, Swee Y Sharp, John J Caldwell, et al.Journal of Medicinal Chemistry|July 19, 2023
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug DiscoveryManjuan Liu, Amin Mirza, P Craig McAndrew, et al.Scientific Reports|October 7, 2016
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoformsAlan M Jones, Isaac M Westwood, James D Osborne, et al.Bioorganic & Medicinal Chemistry Letters|April 22, 2021
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1Birgit Wilding, A Elisa Pasqua, Nicola E A Chessum, et al.ACS Medicinal Chemistry Letters|January 8, 2019
Privileged Structures and Polypharmacology within and between Protein FamiliesJoshua Meyers, Nicola E A Chessum, Salyha Ali, et al.Medchemcomm|October 18, 2016
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9Carl S Rye, Nicola E A Chessum, Scott Lamont, et al.Journal of Medicinal Chemistry|April 5, 2023
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesA Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, et al.Journal of Medicinal Chemistry|December 23, 2016
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenMatthew D Cheeseman, Nicola E A Chessum, Carl S Rye, et al.Pageof 2