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Nature Communications|March 2, 2023
A covalent BTK ternary complex compatible with targeted protein degradationJames Schiemer, Andrew Maxwell, Reto Horst, et al.
Methods in Molecular Biology (Clifton, N.J.)|February 27, 2018
Biophysical Interactions of Direct AMPK ActivatorsRavi G Kurumbail, Graham M West, Venkatasubramanian Dharmarajan, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 26, 2025
Applications of contemporary tools to measure plasma protein binding of targeted protein degradersMark Niosi, Sam Zhang, Woodrow Burchett, et al.
The Biochemical Journal|December 5, 2015
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activatorsFrancis Rajamohan, Allan R Reyes, Richard K Frisbie, et al.
Structure (London, England : 1993)|October 1, 2013
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometryRachelle R Landgraf, Devrishi Goswami, Francis Rajamohan, et al.
Molecular Cell|October 13, 2009
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligasesMin Zhuang, Matthew F Calabrese, Jiang Liu, et al.
Nature Chemical Biology|November 17, 2020
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexesJames Schiemer, Reto Horst, Yilin Meng, et al.
Journal of Medicinal Chemistry|July 24, 2018
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)Tim F Ryder, Matthew F Calabrese, Gregory S Walker, et al.
Cancer Cell|March 25, 2014
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerGuoqiang Li, Weimin Ci, Subhradip Karmakar, et al.
RSC Medicinal Chemistry|March 22, 2024
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complexAliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, et al.
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