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Cell Reports
|
January 16, 2020
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models
Jesse E Hanson, Keran Ma, Justin Elstrott, et al.
Journal of Medicinal Chemistry
|
January 9, 2014
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, et al.
Journal of Medicinal Chemistry
|
March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Huifen Chen, Matthew Volgraf, Steven Do, et al.
Journal of Medicinal Chemistry
|
February 28, 2016
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Matthew Volgraf, Benjamin D Sellers, Yu Jiang, et al.
Journal of Medicinal Chemistry
|
March 22, 2021
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Jack A Terrett, Huifen Chen, Daniel G Shore, et al.
Journal of Medicinal Chemistry
|
March 3, 2024
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Jack A Terrett, Justin Q Ly, Paula Katavolos, et al.
The Journal of Experimental Medicine
|
February 23, 2021
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
Alessia Balestrini, Victory Joseph, Michelle Dourado, et al.
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of 3
Search research articles
Search
Showing results (21-30 of 27) with videos related to
Sort By:
Page
of 3
You have reached the last page of results.
This site can display upto 27 results.
Cell Reports
|
January 16, 2020
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models
Jesse E Hanson, Keran Ma, Justin Elstrott, et al.
Journal of Medicinal Chemistry
|
January 9, 2014
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, et al.
Journal of Medicinal Chemistry
|
March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Huifen Chen, Matthew Volgraf, Steven Do, et al.
Journal of Medicinal Chemistry
|
February 28, 2016
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Matthew Volgraf, Benjamin D Sellers, Yu Jiang, et al.
Journal of Medicinal Chemistry
|
March 22, 2021
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Jack A Terrett, Huifen Chen, Daniel G Shore, et al.
Journal of Medicinal Chemistry
|
March 3, 2024
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Jack A Terrett, Justin Q Ly, Paula Katavolos, et al.
The Journal of Experimental Medicine
|
February 23, 2021
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
Alessia Balestrini, Victory Joseph, Michelle Dourado, et al.
Page
of 3