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Nature Immunology|February 10, 2025
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variantsShouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, et al.Journal of Medicinal Chemistry|January 14, 2026
Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K DegradersThiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Anna Iermolaieva, et al.Cancer Research|January 4, 2024
Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial CarcinomaSana Hosni, Viola Kilian, Niklas Klümper, et al.Journal of Clinical Immunology|November 16, 2021
Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis LocusAnnemarie Steiner, Thomas Reygaerts, Alessandra Pontillo, et al.Molecular Cell|August 26, 2025
A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongationJennifer R Devlin, Ben Martin, Nenad Bartonicek, et al.Cell Chemical Biology|March 26, 2019
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle PhenotypeCalla M Olson, Yanke Liang, Alan Leggett, et al.Nucleic Acids Research|October 13, 2023
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNAAnn Kristin de Regt, Kanchan Anand, Katrin Ciupka, et al.American Journal of Human Genetics|November 8, 2018
Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis SimplexMaria-Teresa Romano, Aylar Tafazzoli, Maximilian Mattern, et al.Cell Host & Microbe|December 20, 2014
Nef proteins of epidemic HIV-1 group O strains antagonize human tetherinSilvia F Kluge, Katharina Mack, Shilpa S Iyer, et al.Bioorganic & Medicinal Chemistry Letters|February 28, 2024
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screeningGeorge Hartman, Paul Humphries, Robert Hughes, et al.Pageof 18