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Chemical Research in Toxicology|August 25, 2009
Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomesHao Chen, Michael Zientek, Mehran Jalaie, et al.Bioorganic & Medicinal Chemistry Letters|May 8, 2007
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitorsDaniel D Holsworth, Mehran Jalaie, Thomas Belliotti, et al.Analytical Biochemistry|November 23, 2006
Binding thermodynamics of substituted diaminopyrimidine renin inhibitorsRonald W Sarver, Jeanette Peevers, Wayne L Cody, et al.Journal of Medicinal Chemistry|December 30, 2003
Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracyJon A Erickson, Mehran Jalaie, Daniel H Robertson, et al.Journal of Chemical Information and Modeling|July 10, 2026
Strategies for Identifying Molecules of Interest in Large Chemical SpacesRaphael Klein, Sascha Jung, Alexander Neumann, et al.Bioorganic & Medicinal Chemistry|June 19, 2007
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitorsNoel A Powell, Fred L Ciske, Cuiman Cai, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 21, 2006
Metabolic aromatization of N-alkyl-1,2,3,4-tetrahydroquinoline substructures to quinolinium by human liver microsomes and horseradish peroxidaseChungang Gu, Roxane Collins, Daniel D Holsworth, et al.Bioorganic & Medicinal Chemistry Letters|February 17, 2006
Ketopiperazine-based renin inhibitors: optimization of the "C" ringDaniel D Holsworth, Cuiman Cai, Xue-Min Cheng, et al.ACS Medicinal Chemistry Letters|September 28, 2018
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated KinaseTed W Johnson, Ben Bolanos, Alexei Brooun, et al.Plos One|June 24, 2011
A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelMartin F Strand, Steven R Wilson, Jennifer L Dembinski, et al.Pageof 4