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Organic Letters|October 22, 2004
Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclizationNoel A Powell, Fred L Ciske, Emma C Clay, et al.Journal of Medicinal Chemistry|March 12, 2013
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitorAndrew Voronkov, Daniel D Holsworth, Jo Waaler, et al.Bioorganic & Medicinal Chemistry Letters|April 30, 2013
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activatorsChuangxing Guo, Angelica Linton, Mehran Jalaie, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2012
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γAgustin Casimiro-Garcia, Ronald J Heemstra, Christopher F Bigge, et al.The Journal of Biological Chemistry|March 17, 2004
Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase betaIda Katrine Lund, Henrik Sune Andersen, Lars Fogh Iversen, et al.Cancer Research|March 30, 2013
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growthTed Lau, Emily Chan, Marinella Callow, et al.Journal of Medicinal Chemistry|May 12, 2011
Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γAgustin Casimiro-Garcia, Gary F Filzen, Declan Flynn, et al.Journal of Medicinal Chemistry|August 29, 2012
Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancerJ Jean Cui, Michele McTigue, Mitchell Nambu, et al.Journal of Medicinal Chemistry|December 5, 2025
Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 InhibitorGary M Gallego, Cynthia Palmer, Suvi Orr, et al.Journal of Medicinal Chemistry|December 28, 2020
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)Hengmiao Cheng, Suvi T M Orr, Simon Bailey, et al.Pageof 4