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Journal of Medicinal Chemistry|March 20, 2023
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1Rebecca A Gallego, Louise Bernier, Hui Chen, et al.Journal of Medicinal Chemistry|December 9, 2024
Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of CancerRebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, et al.Cancer Cell|March 11, 2025
CDK4 selective inhibition improves preclinical anti-tumor efficacy and safetyCynthia L Palmer, Britton Boras, Bernadette Pascual, et al.Journal of Medicinal Chemistry|January 13, 2016
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR MutantsHengmiao Cheng, Sajiv K Nair, Brion W Murray, et al.Pageof 4