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Archives of Biochemistry and Biophysics|February 28, 2026
Rodent models with neuraminidase deficienciesMelike Can, Hande Basırlı, Volkan SeyrantepeMetabolic Brain Disease|February 25, 2026
Intrathecal delivery of AAVrh10-mHexa combined with anti-inflammatory treatment reduces neuropathological markers and extends the lifespan of mice with early-onset Tay-Sachs diseaseMelike Can, Jerome Ausseil, Volkan SeyrantepePlos One|March 17, 2023
Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse modelTugce Sengul, Melike Can, Nurselin Ateş, et al.Molecular Genetics and Metabolism|January 23, 2024
Lithium treatment rescues dysfunctional autophagy in the cell models of Tay-Sachs diseaseHande Basirli, Melike Can, Tugce Sengul, et al.Journal of Lipids|April 16, 2024
Gangliosides as Therapeutic Targets for Neurodegenerative DiseasesOrhan Kerim Inci, Hande Basırlı, Melike Can, et al.Glycoconjugate Journal|December 29, 2025
Mass spectrometric profiling reveals alterations in N-Glycans and O-Glycans in Tay-Sachs disease under Autophagy-Induced conditionsMelike Can, Hande Basirli, Chunsheng Jin, et al.Frontiers in Molecular Biosciences|August 25, 2022
Analysis of Brain Lipids in the Early-Onset Tay-Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3Melike Can, Tugce Sengül, Secil Akyildiz Demir, et al.Pageof 1