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The Journal of Biological Chemistry|November 28, 2013
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregationMorgan E Desantis, Elizabeth A Sweeny, David Snead, et al.
Nature Chemical Biology|November 17, 2009
A synergistic small-molecule combination directly eradicates diverse prion strain structuresBlake E Roberts, Martin L Duennwald, Huan Wang, et al.
Neuron|March 12, 2019
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell DeathFatima Gasset-Rosa, Shan Lu, Haiyang Yu, et al.
Molecular Cell|May 13, 2026
High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effectsJeremy J Ryan, Karlie R Miller, Anuradhika Puri, et al.
The Biochemical Journal|August 22, 2014
Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assemblyKatelyn M Seither, Heather A McMahon, Nikita Singh, et al.
Traffic (Copenhagen, Denmark)|September 4, 2008
A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cellsSandra Maday, Eric Anderson, Henry C Chang, et al.
Biorxiv : the Preprint Server for Biology|January 30, 2023
MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathyYeawon Kim, Chuang Li, Chenjian Gu, et al.
Nature Communications|June 5, 2019
Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregaseAlexandrea N Rizo, JiaBei Lin, Stephanie N Gates, et al.
Current Biology : CB|September 17, 2013
Fission yeast does not age under favorable conditions, but does so after stressMiguel Coelho, Aygül Dereli, Anett Haese, et al.
Science Advances|June 24, 2026
Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43Katie E Copley, Megan M Dykstra, Morgan R Miller, et al.
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