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Molecular Metabolism|September 20, 2024
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male miceRaian E Contreras, Tim Gruber, Ismael González-García, et al.Biorxiv : the Preprint Server for Biology|June 15, 2026
Maternal Thyroid Supplementation Prevents Autistic-relevant Social Behavior and Hypothalamic Oxytocin Depletion Produced by Developmental Exposure to Environmental ToxicantsElena V Kozlova, Maximillian E Denys, Anthony E Bishay, et al.Journal of Medicinal Chemistry|November 11, 2005
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activityCaterina Fattorusso, Sandra Gemma, Stefania Butini, et al.Diabetologia|March 7, 2020
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesitySigrid Jall, Meri De Angelis, Anne-Marie Lundsgaard, et al.Journal of Medicinal Chemistry|December 12, 2018
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the HypothalamusEleni Kyriakou, Stefanie Schmidt, Garron T Dodd, et al.Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine|May 21, 2016
Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman PrimatesDieter Ory, Sofie Celen, Rik Gijsbers, et al.Journal of Medicinal Chemistry|August 23, 2016
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptorDevin M Swanson, Brad M Savall, Kevin J Coe, et al.Biorxiv : the Preprint Server for Biology|March 27, 2026
Midbrain Tet1 dosage defines inter-individual binge-eating susceptibilityTim Gruber, Robert A Chesters, Luca Fagnocchi, et al.Journal of Medicinal Chemistry|December 17, 2008
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behaviorStefania Butini, Sandra Gemma, Giuseppe Campiani, et al.Diabetes|August 31, 2018
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1Katrin Pfuhlmann, Sonja C Schriever, Peter Baumann, et al.Pageof 5