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ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
ACS Chemical Neuroscience|September 13, 2016
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256Michael D Grannan, Catharine A Mielnik, Sean P Moran, et al.
ACS Medicinal Chemistry Letters|October 24, 2017
Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidinesMasahito Abe, Mabel Seto, Rocco G Gogliotti, et al.
Neuropharmacology|December 1, 2015
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effectsRobert W Gould, Michael T Nedelcovych, Xuewen Gong, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 28, 2015
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyHilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's diseaseCarrie K Jones, Michael Bubser, Analisa D Thompson, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMsJulie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
ACS Chemical Neuroscience|June 23, 2026
Discovery of VU6066098: A Selective and CNS-Penetrant mGlu2 NAM with Robust Antidepressant-, Antipsychotic-, and Procognitive-like Activity in RodentsJeremy S Coleman, Rory A Capstick, Sichen Chang, et al.
ACS Chemical Neuroscience|September 24, 2024
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)Julie L Engers, Logan A Baker, Sichen Chang, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|October 10, 2008
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in ratsCarrie K Jones, Ashley E Brady, Albert A Davis, et al.
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