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Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|August 29, 2015
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like EffectsRobert W Gould, Russell J Amato, Michael Bubser, et al.
Bioorganic & Medicinal Chemistry Letters|April 27, 2017
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacologyBruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|January 21, 2014
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100Nellie E Byun, Michael Grannan, Michael Bubser, et al.
ACS Chemical Neuroscience|November 26, 2025
Discovery of VU6052254: A Novel, Potent M1 Positive Allosteric ModulatorJulie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Journal of Medicinal Chemistry|August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine ReceptorJinming Li, Douglas L Orsi, Julie L Engers, et al.
ACS Medicinal Chemistry Letters|February 16, 2017
Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of SchizophreniaMichael R Wood, Meredith J Noetzel, Bruce J Melancon, et al.
Bioorganic & Medicinal Chemistry Letters|May 23, 2019
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidateDarren W Engers, Bruce J Melancon, Allison R Gregro, et al.
ACS Chemical Neuroscience|August 20, 2014
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodentsMichael Bubser, Thomas M Bridges, Ditte Dencker, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.
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