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Antiviral Research|December 23, 2018
Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factorManunya Nuth, Hancheng Guan, Yuhong Xiao, et al.The Ocular Surface|November 8, 2020
Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesisHancheng Guan, Manunya Nuth, Vivian Lee, et al.Bioorganic & Medicinal Chemistry|September 6, 2002
Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregationMichael H Parker, Robert Chen, Kelly A Conway, et al.Antiviral Research|January 5, 2023
A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potentialHancheng Guan, Manunya Nuth, Stuart N Isaacs, et al.Journal of Medicinal Chemistry|November 12, 2013
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)David F McComsey, Virginia L Smith-Swintosky, Michael H Parker, et al.Bioorganic & Medicinal Chemistry Letters|April 20, 2010
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leadsYifang Huang, Eric D Strobel, Chih Y Ho, et al.Journal of Medicinal Chemistry|April 25, 2009
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studiesMichael H Parker, Virginia L Smith-Swintosky, David F McComsey, et al.Bioorganic & Medicinal Chemistry Letters|May 22, 2018
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapyTianbao Lu, Carsten Schubert, Maxwell D Cummings, et al.Journal of Medicinal Chemistry|August 10, 2007
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar leadEllen W Baxter, Kelly A Conway, Ludo Kennis, et al.Pageof 2