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Michael J Witty

Showing results (11-20 of 23) with videos related to

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Journal of Medicinal Chemistry|October 9, 2013
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activityYassir Younis, Frederic Douelle, Diego González Cabrera, et al.
Bioorganic & Medicinal Chemistry Letters|November 25, 2017
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)Tsutomu Akama, Yong-Kang Zhang, Yvonne R Freund, et al.
Journal of Medicinal Chemistry|February 27, 2014
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1Claire Le Manach, Diego Gonzàlez Cabrera, Frederic Douelle, et al.
Journal of Medicinal Chemistry|November 30, 2012
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridinesDiego González Cabrera, Frederic Douelle, Yassir Younis, et al.
Plos Pathogens|November 3, 2020
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugsFederica Giordani, Daniel Paape, Isabel M Vincent, et al.
Journal of Medicinal Chemistry|January 23, 2014
2,4-Diaminothienopyrimidines as orally active antimalarial agentsDiego González Cabrera, Claire Le Manach, Frederic Douelle, et al.
Journal of Medicinal Chemistry|March 7, 2012
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potentialYassir Younis, Frederic Douelle, Tzu-Shean Feng, et al.
Journal of Medicinal Chemistry|October 27, 2015
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial ImidazopyridazinesClaire Le Manach, Tanya Paquet, Christel Brunschwig, et al.
Journal of Medicinal Chemistry|March 18, 2022
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal TrypanosomiasisAlasdair Smith, Richard J Wall, Stephen Patterson, et al.
Journal of Medicinal Chemistry|October 18, 2016
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life CycleClaire Le Manach, Aloysius T Nchinda, Tanya Paquet, et al.
Pageof 3

Showing results (11-20 of 23) with videos related to

Sort By:
Pageof 3
Journal of Medicinal Chemistry|October 9, 2013
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activityYassir Younis, Frederic Douelle, Diego González Cabrera, et al.
Bioorganic & Medicinal Chemistry Letters|November 25, 2017
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)Tsutomu Akama, Yong-Kang Zhang, Yvonne R Freund, et al.
Journal of Medicinal Chemistry|February 27, 2014
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1Claire Le Manach, Diego Gonzàlez Cabrera, Frederic Douelle, et al.
Journal of Medicinal Chemistry|November 30, 2012
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridinesDiego González Cabrera, Frederic Douelle, Yassir Younis, et al.
Plos Pathogens|November 3, 2020
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugsFederica Giordani, Daniel Paape, Isabel M Vincent, et al.
Journal of Medicinal Chemistry|January 23, 2014
2,4-Diaminothienopyrimidines as orally active antimalarial agentsDiego González Cabrera, Claire Le Manach, Frederic Douelle, et al.
Journal of Medicinal Chemistry|March 7, 2012
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potentialYassir Younis, Frederic Douelle, Tzu-Shean Feng, et al.
Journal of Medicinal Chemistry|October 27, 2015
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial ImidazopyridazinesClaire Le Manach, Tanya Paquet, Christel Brunschwig, et al.
Journal of Medicinal Chemistry|March 18, 2022
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal TrypanosomiasisAlasdair Smith, Richard J Wall, Stephen Patterson, et al.
Journal of Medicinal Chemistry|October 18, 2016
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life CycleClaire Le Manach, Aloysius T Nchinda, Tanya Paquet, et al.
Pageof 3