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Innovations in Clinical Neuroscience|August 24, 2011
How Adaptive Trial Designs can Increase Efficiency in Psychiatric Drug Development: A Case StudyJoan Shen, Sheldon Preskorn, Vladimir Dragalin, et al.
Journal of Biopharmaceutical Statistics|November 21, 2007
Adaptive designs in clinical drug development: opportunities, challenges, and scope reflections following PhRMA's November 2006 workshopMichael Krams, Carl-Fredrik Burman, Vladimir Dragalin, et al.
Journal of Pharmacokinetics and Pharmacodynamics|February 12, 2009
Evaluation of structural models to describe the effect of placebo upon the time course of major depressive disorderElizabeth Y Shang, Megan A Gibbs, Jaren W Landen, et al.
Clinical Trials (London, England)|March 27, 2010
A Bayesian dose-finding trial with adaptive dose expansion to flexibly assess efficacy and safety of an investigational drugScott M Berry, Walter Spinelli, Gary S Littman, et al.
Movement Disorders : Official Journal of the Movement Disorder Society|September 2, 2008
Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and ParkinsonismJohn G Nutt, Steven A Gunzler, Trish Kirchhoff, et al.
Nature Reviews. Drug Discovery|July 13, 2026
Design, simulate, refine: simulation-guided clinical trials for accelerated drug developmentElias Laurin Meyer, Tim Friede, Andrew P Grieve, et al.
Alzheimer'S & Dementia (Amsterdam, Netherlands)|January 10, 2019
Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid-to-late life in an epidemiological sampleRosemary A Abbott, Caroline Skirrow, Martha Jokisch, et al.
Journal of Biopharmaceutical Statistics|November 21, 2007
Innovative approaches for designing and analyzing adaptive dose-ranging trialsBjörn Bornkamp, Frank Bretz, Alex Dmitrienko, et al.
Expert Review of Neurotherapeutics|December 27, 2014
Charting a path toward combination therapy for Alzheimer's diseaseDiane Stephenson, Dan Perry, Cynthia Bens, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|June 21, 2007
Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic strokeGiora Z Feuerstein, Margaret M Zaleska, Michael Krams, et al.
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