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Molecules (Basel, Switzerland)|February 15, 2022
Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-DioxidesWen Qi, Pooja Yadav, Cho R Hong, et al.
Chemical Communications (Cambridge, England)|September 25, 2014
Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreductionPooja Yadav, Andrew J Marshall, Jóhannes Reynisson, et al.
Journal of Pharmaceutical Sciences|September 13, 2014
Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solutionYongchuan Gu, Jagdish K Jaiswal, Jingli Wang, et al.
Journal of the American Chemical Society|February 10, 2010
Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)Sujata S Shinde, Andrej Maroz, Michael P Hay, et al.
Cancer Cell|July 5, 2008
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagySandra Turcotte, Denise A Chan, Patrick D Sutphin, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|December 15, 2011
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxiaJingli Wang, Annika Foehrenbacher, Jiechuang Su, et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms|August 14, 2024
Megakaryocyte maturation involves activation of the adaptive unfolded protein responseMifra Faiz, Maggie L Kalev-Zylinska, Caitlin Dunstan-Harrison, et al.
Journal of Medicinal Chemistry|February 18, 2005
Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer culturesFrederik B Pruijn, Joanna R Sturman, H D Sarath Liyanage, et al.
Chemistry, an Asian Journal|January 8, 2019
Hypoxia-Activated Prodrugs of PERK InhibitorsLydia P Liew, Dean C Singleton, Way W Wong, et al.
RSC Medicinal Chemistry|July 24, 2023
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisationWay W Wong, Sophia F O'Brien-Gortner, Robert F Anderson, et al.
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