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Journal of Medicinal Chemistry|January 9, 2004
DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamineMichael P Hay, Frederik B Pruijn, Swarna A Gamage, et al.
Organic & Biomolecular Chemistry|April 17, 2014
Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000Robert F Anderson, Pooja Yadav, Deepa Patel, et al.
Molecular Cancer|June 14, 2013
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapyLaura K Green, Sophie P Syddall, Kendall M Carlin, et al.
Journal of Chemical Information and Modeling|March 4, 2017
Chemical Space Mimicry for Drug DiscoveryWilliam Yuan, Dadi Jiang, Dhanya K Nambiar, et al.
Journal of Medicinal Chemistry|July 15, 2024
Identification of 6-Anilino Imidazo[4,5-c]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as RadiosensitizersCho R Hong, Lydia P Liew, Way W Wong, et al.
Molecules (Basel, Switzerland)|October 27, 2020
Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic CytotoxicityChris P Guise, Maria R Abbattista, Robert F Anderson, et al.
Molecular Cancer Therapeutics|June 17, 2016
Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple MyelomaDadi Jiang, Arvin B Tam, Muthuraman Alagappan, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|August 25, 2010
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumorsKevin O Hicks, Bronwyn G Siim, Jagdish K Jaiswal, et al.
Journal of Medicinal Chemistry|December 19, 2017
Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole AlkylsulfonamidesMuriel Bonnet, Cho Rong Hong, Way Wua Wong, et al.
Frontiers in Pharmacology|August 30, 2017
Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in MiceYongchuan Gu, Tony T-A Chang, Jingli Wang, et al.
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