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Bioorganic & Medicinal Chemistry Letters|July 17, 2013
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitorsRaymond A Ng, Minghua Sun, Simeon Bowers, et al.Carbohydrate Polymers|December 23, 2023
The European Polysaccharide Network of Excellence (EPNOE) research roadmap 2040: Advanced strategies for exploiting the vast potential of polysaccharides as renewable bioresourcesMartin Gericke, Adérito J R Amaral, Tatiana Budtova, et al.Bioorganic & Medicinal Chemistry Letters|August 8, 2009
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitorsAnh P Truong, Danielle L Aubele, Gary D Probst, et al.Bioorganic & Medicinal Chemistry Letters|November 30, 2010
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegenerationGary D Probst, Simeon Bowers, Jennifer M Sealy, et al.Bioorganic & Medicinal Chemistry Letters|June 20, 2013
Orally available and efficacious α4β1/α4β7 integrin inhibitorsYing-zi Xu, Jenifer L Smith, Christopher M Semko, et al.Bioorganic & Medicinal Chemistry Letters|September 14, 2010
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal modelAnh P Truong, Gergley Tóth, Gary D Probst, et al.Bioorganic & Medicinal Chemistry Letters|September 9, 2010
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl regionGary D Probst, Simeon Bowers, Jennifer M Sealy, et al.Bioorganic & Medicinal Chemistry Letters|August 5, 2011
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegenerationSimeon Bowers, Anh P Truong, R Jeffrey Neitz, et al.Alzheimer'S Research & Therapy|December 31, 2010
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's diseaseGuriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, et al.Journal of Medicinal Chemistry|May 30, 2013
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over NotchGary Probst, Danielle L Aubele, Simeon Bowers, et al.Pageof 25