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The Journal of Biological Chemistry|August 23, 2002
Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesisKathleen C Day, Michael T McCabe, Xin Zhao, et al.
ACS Chemical Biology|December 6, 2013
Long residence time inhibition of EZH2 in activated polycomb repressive complex 2Glenn S Van Aller, Melissa Baker Pappalardi, Heidi M Ott, et al.
Nature|April 7, 2016
Reductive carboxylation supports redox homeostasis during anchorage-independent growthLei Jiang, Alexander A Shestov, Pamela Swain, et al.
Scientific Reports|June 28, 2018
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicingSarah V Gerhart, Wendy A Kellner, Christine Thompson, et al.
Nature Communications|January 23, 2015
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressorsDaniel Zingg, Julien Debbache, Simon M Schaefer, et al.
Oncogenesis|April 21, 2018
MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancersAnastasia Wyce, Jeanne J Matteo, Shawn W Foley, et al.
Molecular Cancer Therapeutics|September 26, 2014
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylationHeidi M Ott, Alan P Graves, Melissa B Pappalardi, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|September 1, 2019
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid TumorsTimothy A Yap, Jane N Winter, Lisa Giulino-Roth, et al.
Plos One|September 7, 2013
BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor modelsAnastasia Wyce, Gopinath Ganji, Kimberly N Smitheman, et al.
Haematologica|December 6, 2018
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-<i>trans</i> retinoic acid in acute myeloid leukemia across subtypesKimberly N Smitheman, Tesa M Severson, Satyajit R Rajapurkar, et al.
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