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Journal of Medicinal Chemistry|December 15, 2017
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)Nicola E A Chessum, Swee Y Sharp, John J Caldwell, et al.Journal of Medicinal Chemistry|February 7, 2023
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement ProbesFrançois Saint-Dizier, Thomas P Matthews, Aaron M Gregson, et al.Journal of Medicinal Chemistry|July 19, 2023
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug DiscoveryManjuan Liu, Amin Mirza, P Craig McAndrew, et al.Bioorganic & Medicinal Chemistry Letters|December 10, 2008
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZLloyd G Czaplewski, Ian Collins, E Andrew Boyd, et al.Chemical Science|March 12, 2026
Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancerPrecious I A Popoola, Thomas L Allam, Rebecca J Lilley, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 12, 2012
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activityTimothy A Yap, Mike I Walton, Kyla M Grimshaw, et al.Scientific Reports|October 7, 2016
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoformsAlan M Jones, Isaac M Westwood, James D Osborne, et al.Science (New York, N.Y.)|September 20, 2008
An inhibitor of FtsZ with potent and selective anti-staphylococcal activityDavid J Haydon, Neil R Stokes, Rebecca Ure, et al.Journal of Medicinal Chemistry|February 20, 2019
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-EndoribonucleaseGiampiero Colombano, John J Caldwell, Thomas P Matthews, et al.Bioorganic & Medicinal Chemistry Letters|November 30, 2013
Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZNeil R Stokes, Nicola Baker, James M Bennett, et al.Pageof 15