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Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|August 16, 2025
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse modelVanessa O Torres, Michelle E Pizzo, Darren Chan, et al.
Nature Communications|February 20, 2025
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistributionNathalie Khoury, Michelle E Pizzo, Claire B Discenza, et al.
Science Translational Medicine|May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeysMihalis S Kariolis, Robert C Wells, Jennifer A Getz, et al.
The Journal of Experimental Medicine|February 28, 2022
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzymeAnnie Arguello, Cathal S Mahon, Meredith E K Calvert, et al.
Cell Reports|July 24, 2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large moleculesRobert C Wells, Padma Akkapeddi, Darren Chan, et al.
Molecular Neurodegeneration|June 11, 2022
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaDan Xia, Steve Lianoglou, Thomas Sandmann, et al.
Nature Communications|August 19, 2023
CD98hc is a target for brain delivery of biotherapeuticsKylie S Chew, Robert C Wells, Arash Moshkforoush, et al.
Science (New York, N.Y.)|August 7, 2025
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIAMichelle E Pizzo, Edward D Plowey, Nathalie Khoury, et al.
Cell|August 27, 2021
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologicTodd Logan, Matthew J Simon, Anil Rana, et al.
Nature Neuroscience|January 12, 2023
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease modelsBettina van Lengerich, Lihong Zhan, Dan Xia, et al.
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