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The Journal of Biological Chemistry|January 2, 2019
A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonistsRahul Patil, Biswaranjan Mohanty, Bonan Liu, et al.
Cell|January 9, 2026
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplexChristopher J Lupton, Charles Bayly-Jones, Shuqi Dong, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 1, 2017
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmissionRebecca E Yarwood, Wendy L Imlach, TinaMarie Lieu, et al.
Science Signaling|April 3, 2020
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonistsAlexander Gillis, Arisbel B Gondin, Andrea Kliewer, et al.
The Journal of Biological Chemistry|January 30, 2021
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomesQuynh N Mai, Priyank Shenoy, Tim Quach, et al.
Nature Communications|July 14, 2017
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapyEunice E To, Ross Vlahos, Raymond Luong, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 18, 2020
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory painNestor N Jimenez-Vargas, Jing Gong, Matthew J Wisdom, et al.
Science Translational Medicine|June 2, 2017
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain reliefDane D Jensen, TinaMarie Lieu, Michelle L Halls, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 18, 2018
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndromeNestor N Jimenez-Vargas, Luke A Pattison, Peishen Zhao, et al.
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