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Miles Congreve

Showing results (31-40 of 56) with videos related to

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Structure (London, England : 1993)|September 3, 2011
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeineAndrew S Doré, Nathan Robertson, James C Errey, et al.
Journal of Medicinal Chemistry|January 7, 2012
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug designMiles Congreve, Stephen P Andrews, Andrew S Doré, et al.
Journal of Medicinal Chemistry|March 23, 2013
Biophysical fragment screening of the β1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug designJohn A Christopher, Jason Brown, Andrew S Doré, et al.
Nature|December 8, 2016
Intracellular allosteric antagonism of the CCR9 receptorChristine Oswald, Mathieu Rappas, James Kean, et al.
Journal of Medicinal Chemistry|February 24, 2007
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretaseMiles Congreve, David Aharony, Jeffrey Albert, et al.
Chemmedchem|March 12, 2014
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocketSusanne M Saalau-Bethell, Valerio Berdini, Anne Cleasby, et al.
Journal of Medicinal Chemistry|February 20, 2018
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) X-ray StructuresJohn A Christopher, Zoltán Orgován, Miles Congreve, et al.
Journal of Medicinal Chemistry|July 31, 2015
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)John A Christopher, Sarah J Aves, Kirstie A Bennett, et al.
Alzheimer'S Research & Therapy|April 22, 2021
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M<sub>1</sub> receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose studyCharlotte Bakker, Tim Tasker, Jan Liptrot, et al.
British Journal of Clinical Pharmacology|April 23, 2021
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M<sub>1</sub> -acetylcholine receptor agonist: A randomized cross-over trialCharlotte Bakker, Samantha Prins, Jan Liptrot, et al.
Pageof 6

Showing results (31-40 of 56) with videos related to

Sort By:
Pageof 6
Structure (London, England : 1993)|September 3, 2011
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeineAndrew S Doré, Nathan Robertson, James C Errey, et al.
Journal of Medicinal Chemistry|January 7, 2012
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug designMiles Congreve, Stephen P Andrews, Andrew S Doré, et al.
Journal of Medicinal Chemistry|March 23, 2013
Biophysical fragment screening of the β1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug designJohn A Christopher, Jason Brown, Andrew S Doré, et al.
Nature|December 8, 2016
Intracellular allosteric antagonism of the CCR9 receptorChristine Oswald, Mathieu Rappas, James Kean, et al.
Journal of Medicinal Chemistry|February 24, 2007
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretaseMiles Congreve, David Aharony, Jeffrey Albert, et al.
Chemmedchem|March 12, 2014
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocketSusanne M Saalau-Bethell, Valerio Berdini, Anne Cleasby, et al.
Journal of Medicinal Chemistry|February 20, 2018
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) X-ray StructuresJohn A Christopher, Zoltán Orgován, Miles Congreve, et al.
Journal of Medicinal Chemistry|July 31, 2015
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)John A Christopher, Sarah J Aves, Kirstie A Bennett, et al.
Alzheimer'S Research & Therapy|April 22, 2021
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M<sub>1</sub> receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose studyCharlotte Bakker, Tim Tasker, Jan Liptrot, et al.
British Journal of Clinical Pharmacology|April 23, 2021
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M<sub>1</sub> -acetylcholine receptor agonist: A randomized cross-over trialCharlotte Bakker, Samantha Prins, Jan Liptrot, et al.
Pageof 6