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ACS Medicinal Chemistry Letters|May 26, 2015
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' MoietyZilun Hu, Pancras C Wong, Paul J Gilligan, et al.Bioorganic & Medicinal Chemistry|April 14, 2016
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime groupJames R Corte, Tianan Fang, Donald J P Pinto, et al.Journal of Medicinal Chemistry|January 11, 2014
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitorsMimi L Quan, Pancras C Wong, Cailan Wang, et al.Bioorganic & Medicinal Chemistry Letters|July 9, 2017
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potencyJames R Corte, Wu Yang, Tianan Fang, et al.Bioorganic & Medicinal Chemistry Letters|August 18, 2020
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studiesZilun Hu, Cailan Wang, Peter W Glunz, et al.Bioorganic & Medicinal Chemistry Letters|May 30, 2006
1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor XaDonald J P Pinto, Michael J Orwat, Mimi L Quan, et al.Bioorganic & Medicinal Chemistry Letters|March 3, 2015
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moietiesDonald J P Pinto, Joanne M Smallheer, James R Corte, et al.Journal of Medicinal Chemistry|November 19, 2014
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activityJon J Hangeland, Todd J Friends, Karen A Rossi, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2015
Novel phenylalanine derived diamides as Factor XIa inhibitorsLeon M Smith, Michael J Orwat, Zilun Hu, et al.Journal of Medicinal Chemistry|October 28, 2017
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)Donald J P Pinto, Michael J Orwat, Leon M Smith, et al.Pageof 3