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Journal of Medicinal Chemistry
|
November 15, 2013
Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice
Chun-Ping Chang, Chien-Huang Wu, Jen-Shin Song, et al.
Journal of Medicinal Chemistry
|
December 8, 2015
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
Yi-Hui Peng, Shau-Hua Ueng, Chen-Tso Tseng, et al.
Journal of Medicinal Chemistry
|
June 18, 2009
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice
Chien-Huang Wu, Ming-Shiu Hung, Jen-Shin Song, et al.
Journal of Medicinal Chemistry
|
December 7, 2010
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
Chun-Hsu Yao, Jen-Shin Song, Chiung-Tong Chen, et al.
Journal of Medicinal Chemistry
|
January 22, 2020
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, et al.
Journal of Medicinal Chemistry
|
September 9, 2015
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening
Jian-Sung Wu, Shu-Yu Lin, Fang-Yu Liao, et al.
Journal of Medicinal Chemistry
|
December 15, 2015
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy
Shu-Yu Lin, Teng-Kuang Yeh, Ching-Chuan Kuo, et al.
Bioorganic Chemistry
|
March 2, 2018
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Shu-Yu Lin, Teng-Kuang Yeh, Jen-Shin Song, et al.
European Journal of Medicinal Chemistry
|
December 20, 2021
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
Teng-Kuang Yeh, Jen-Shin Song, Po-Wei Chang, et al.
EMBO Molecular Medicine
|
March 22, 2025
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, et al.
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of 3
Search research articles
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Showing results (21-30 of 30) with videos related to
Sort By:
Page
of 3
You have reached the last page of results.
This site can display upto 30 results.
Journal of Medicinal Chemistry
|
November 15, 2013
Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice
Chun-Ping Chang, Chien-Huang Wu, Jen-Shin Song, et al.
Journal of Medicinal Chemistry
|
December 8, 2015
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
Yi-Hui Peng, Shau-Hua Ueng, Chen-Tso Tseng, et al.
Journal of Medicinal Chemistry
|
June 18, 2009
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice
Chien-Huang Wu, Ming-Shiu Hung, Jen-Shin Song, et al.
Journal of Medicinal Chemistry
|
December 7, 2010
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
Chun-Hsu Yao, Jen-Shin Song, Chiung-Tong Chen, et al.
Journal of Medicinal Chemistry
|
January 22, 2020
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, et al.
Journal of Medicinal Chemistry
|
September 9, 2015
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening
Jian-Sung Wu, Shu-Yu Lin, Fang-Yu Liao, et al.
Journal of Medicinal Chemistry
|
December 15, 2015
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy
Shu-Yu Lin, Teng-Kuang Yeh, Ching-Chuan Kuo, et al.
Bioorganic Chemistry
|
March 2, 2018
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Shu-Yu Lin, Teng-Kuang Yeh, Jen-Shin Song, et al.
European Journal of Medicinal Chemistry
|
December 20, 2021
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
Teng-Kuang Yeh, Jen-Shin Song, Po-Wei Chang, et al.
EMBO Molecular Medicine
|
March 22, 2025
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, et al.
Page
of 3