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The Journal of Biological Chemistry
|
August 28, 2002
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux
Raymond H See, Rosalinda A Caday-Malcolm, Roshni R Singaraja, et al.
Journal of Medicinal Chemistry
|
April 19, 2008
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
Lars Johansson, Christopher Fotsch, Michael D Bartberger, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 13, 2013
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism
Paul M Wehn, Paul E Harrington, Timothy J Carlson, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 9, 2007
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors
Chester Yuan, David J St Jean, Qingyian Liu, et al.
Science Translational Medicine
|
December 1, 2012
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
Ian N Foltz, Sylvia Hu, Chadwick King, et al.
Journal of Medicinal Chemistry
|
December 5, 2008
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model
Christopher Fotsch, Michael D Bartberger, Eric A Bercot, et al.
Journal of Medicinal Chemistry
|
May 15, 2010
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
Murielle M Véniant, Clarence Hale, Randall W Hungate, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 17, 2010
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Paul E Harrington, David J St Jean, Jeffrey Clarine, et al.
Nature
|
November 15, 2013
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
David J Lloyd, David J St Jean, Robert J M Kurzeja, et al.
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Showing results (71-80 of 79) with videos related to
Sort By:
Page
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You have reached the last page of results.
This site can display upto 79 results.
The Journal of Biological Chemistry
|
August 28, 2002
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux
Raymond H See, Rosalinda A Caday-Malcolm, Roshni R Singaraja, et al.
Journal of Medicinal Chemistry
|
April 19, 2008
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
Lars Johansson, Christopher Fotsch, Michael D Bartberger, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 13, 2013
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism
Paul M Wehn, Paul E Harrington, Timothy J Carlson, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 9, 2007
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors
Chester Yuan, David J St Jean, Qingyian Liu, et al.
Science Translational Medicine
|
December 1, 2012
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
Ian N Foltz, Sylvia Hu, Chadwick King, et al.
Journal of Medicinal Chemistry
|
December 5, 2008
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model
Christopher Fotsch, Michael D Bartberger, Eric A Bercot, et al.
Journal of Medicinal Chemistry
|
May 15, 2010
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
Murielle M Véniant, Clarence Hale, Randall W Hungate, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 17, 2010
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Paul E Harrington, David J St Jean, Jeffrey Clarine, et al.
Nature
|
November 15, 2013
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
David J Lloyd, David J St Jean, Robert J M Kurzeja, et al.
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of 8