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Transplantation|November 27, 2002
Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapyJohanne Tremblay, Huifang Chen, Junzheng Peng, et al.
Transplantation|April 30, 2003
Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primatesShijie Qi, Shengyun Zhu, Dasheng Xu, et al.
The Journal of Clinical Investigation|December 15, 2007
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in miceNicolas Degauque, Christophe Mariat, James Kenny, et al.
Bioorganic & Medicinal Chemistry Letters|April 2, 2013
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitorsSaul Jaime-Figueroa, Javier De Vicente, Johannes Hermann, et al.
Bioorganic & Medicinal Chemistry Letters|April 2, 2013
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinomeStephen M Lynch, Javier DeVicente, Johannes C Hermann, et al.
Bioorganic & Medicinal Chemistry Letters|September 29, 2014
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazinesJavier de Vicente, Remy Lemoine, Mark Bartlett, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 10, 2012
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodentsDaigen Xu, Yong Kim, Jennifer Postelnek, et al.
Cancer Cell|March 7, 2017
Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma TreatmentAnja Seckinger, Jose Antonio Delgado, Samuel Moser, et al.
Journal of Medicinal Chemistry|December 11, 2012
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo modelsMichael Soth, Johannes C Hermann, Calvin Yee, et al.
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