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Blood|December 24, 2013
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaErika K Keeton, Kristen McEachern, Keith S Dillman, et al.Cell Chemical Biology|December 2, 2019
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 ComplexJessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, et al.Journal of Medicinal Chemistry|November 22, 2021
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 MethyltransferaseSharan K Bagal, Clare Gregson, Daniel H O' Donovan, et al.Molecular Cancer Therapeutics|March 13, 2023
Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination PartnersAatman S Doshi, Susan Cantin, Marylens Hernandez, et al.Journal of Medicinal Chemistry|November 28, 2017
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell LymphomaJames S Scott, Sébastien L Degorce, Rana Anjum, et al.Journal of Medicinal Chemistry|February 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 InhibitorJason D Shields, David Baker, Amber Y S Balazs, et al.Pageof 3