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Biorxiv : the Preprint Server for Biology|December 15, 2025
An Integrated Biophysical Fragment Screening Approach Identifies Novel Binders of the CD28 Immune ReceptorLaura Calvo-Barreiro, Hossam Nada, Moustafa Gabr
Biorxiv : the Preprint Server for Biology|May 13, 2026
Discovery and Optimization of Small Molecule Inhibitors of the SLIT2/ROBO1 Protein-Protein Interaction Using DNA-Encoded LibrariesNelson Garcia-Vazquez, Shaoren Yuan, Moustafa Gabr
Biorxiv : the Preprint Server for Biology|November 24, 2025
Identification of a First-In-Class Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry ScreeningAshraf N Abdo, Hossam Nada, Moustafa Gabr
ACS Medicinal Chemistry Letters|September 18, 2020
Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 SignalingMoustafa Gabr, Ashfaq Ur Rehman, Hai-Feng Chen
Biorxiv : the Preprint Server for Biology|February 6, 2026
Targeting CHI3L1 in Alzheimer's Disease: Optimization of G721-0282 and Functional Evaluation in Astrocyte ModelsBaljit Kaur, Hossam Nada, Longfei Zhang, et al.
Biorxiv : the Preprint Server for Biology|August 6, 2025
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo ValidationSaurabh Upadhyay, Sungwoo Cho, Hossam Nada, et al.
Biorxiv : the Preprint Server for Biology|February 12, 2026
Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein InterfacesHossam Nada, Sungwoo Cho, Ashraf N Abdo, et al.
Biorxiv : the Preprint Server for Biology|August 8, 2025
Small Molecule-Based Blockade of CD28 Suppresses T Cell Costimulation Across Cellular and Mucosal Co-culture ModelsSaurabh Upadhyay, Valerij Talagayev, Sungwoo Cho, et al.
Bioorganic & Medicinal Chemistry Letters|December 23, 2025
AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validationSungwoo Cho, Renjie Zhu, Katarzyna Kuncewicz, et al.
European Journal of Medicinal Chemistry|September 24, 2025
Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal modelsSaurabh Upadhyay, Valerij Talagayev, Sungwoo Cho, et al.
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