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Bioorganic & Medicinal Chemistry Letters|September 4, 2020
Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalizationQing Shi, Zili Xiao, Michael G Yang, et al.Journal of Medicinal Chemistry|April 22, 2010
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521)Scott H Watterson, Zili Xiao, Dharmpal S Dodd, et al.ACS Medicinal Chemistry Letters|March 18, 2016
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical TrialsT G Murali Dhar, Hai-Yun Xiao, Jenny Xie, et al.Journal of Medicinal Chemistry|October 22, 2024
Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) KinaseJennifer X Qiao, David Williams, Patrice Gill, et al.Medchemcomm|August 16, 2018
Identification of potent tricyclic prodrug S1P1 receptor modulatorsDavid Marcoux, Hai-Yun Xiao, T G Murali Dhar, et al.Journal of Medicinal Chemistry|December 2, 2020
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design ApproachesHai-Yun Xiao, Ning Li, James J-W Duan, et al.Journal of Medicinal Chemistry|December 23, 2016
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor ModulatorMichael G Yang, Zili Xiao, T G Murali Dhar, et al.ACS Medicinal Chemistry Letters|June 20, 2020
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse AgonistRobert J Cherney, Lyndon A M Cornelius, Anurag Srivastava, et al.Bioorganic & Medicinal Chemistry Letters|December 14, 2017
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivityHua Gong, David S Weinstein, Zhonghui Lu, et al.ACS Medicinal Chemistry Letters|May 31, 2021
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and PsoriasisQingjie Liu, Hai-Yun Xiao, Douglas G Batt, et al.Pageof 10